Patients with PSOriasis and Suppurative Hidradenitis (PSOSH) share genetic risk factors and are at risk of increased morbidity - Supplementary Material

Patients with PSOriasis and Suppurative Hidradenitis (PSOSH) share genetic risk factors and are at risk of increased morbidity.

Antonia Wiala, MD1, Kareem G Elhage, BA2, Albert T. Young, MD, MAS3, Mark Gregory, MS3, Indra Adrianto, PhD3-7, Li Zhou, MD, MS4-7, Qing-Sheng Mi, MD, PhD4-7, Sugandh Kumar, PhD2, Faye Orcales, BS2, Samuel Yeroushalmi, MD2, Kathryn Haran, BS2, Haley B. Naik 2, Wilson Liao, MD2, Christian Posch MD, PhD1,8-10*
1 Clinic Landstrasse, Department of Dermatology, 1030 Vienna, Austria
2 Department of Dermatology, University of California, San Francisco, CA, USA
3 Center for Bioinformatics, Department of Public Health Sciences, Henry Ford Health, Detroit, MI, USA.
4 Center for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health, Detroit, MI, USA.
5 Henry Ford Health + Michigan State University Health Sciences, East Lansing, MI 48824, USA.
6 Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, MI, USA.
7 Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI, USA.
8 School of Medicine, Sigmund Freud University; 1020 Vienna, Austria
9 Clinic Hietzing, Department of Dermatology, 1130 Vienna, Austria
10 Department of Dermatology and Allergy, School of Medicine, German Cancer Consortium (DKTK), Technical University of Munich, Munich, Germany

Supplemental information
Supplemental Material and Methods

Supplemental Figures
Supplemental Fig. 1 HLA-C*06:02 frequency for healthy, HS-only, PSO-only and PsoSH patients

Supplemental Tables
Supplemental Table 1. Excel Data Sheet, see supplemental Materials and Methods
Supplemental Table 2. Excel Data Sheet, see supplemental Materials and Methods
Supplemental Table 3. Demographics of the All of Us Cohort comparing patients with Hidradenitis suppurativa (HS) only, Psoriasis only and a diagnosis of both HS and psoriasis.
Supplemental Table 4. Multivariate regression analysis of PSO-HS status (versus HS or Pso alone) with comorbidity and quality of life outcomes
Supplemental Table 5. Analyzing patients with high PSO-PRS to patients (upper 50%) compared to those with low PSO-PRS (lower 50%) revealed significant differences regarding disease onset of psoriasis, TNF-alpha response rates and BMI.