Identification of xLEF1 specific target genes in dorsal marginal zone explants of Xenopus laevis. Xenopus laevis

Lef-1 as nuclear transducer of the canonical Wnt signaling pathway acts as regulator of convergent extension (CE) movements. To identify Lef-1 target genes relevant for CE movements we compared the transcriptome of Lef-1 morphant dorsal marginal zone explants with control morphants. Overall design: Dorsal marginal zone explants of CO_MO and LEF_MO injected embryos were analysed in three biological replicates.