Klebsiella pneumoniae Genome sequencing and assembly

Colistin resistance in Klebsiella pneumoniae typically develops through chromosomal gene inactivation or mutations (mgrB, phoPQ) when the strains are exposed to colistin; however, the lipid A phenotypes associated with these changes have not been reported. Here, we examined the sequences of chromosomal loci implicated in colistin resistance and the respective lipid A profiles using eleven pairs of colistin-susceptible and resistant clinical strains identified from the same patients.