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Inactive Crohn’s disease ileal microbiota is linked to promoter methylation of genes involved in inflammation and autoimmunity

NIAID Data Ecosystem2026-03-10 收录

克罗恩病微生物组

DNA甲基化与疾病

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA486505 数据链接链接失效反馈

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资源简介：

The present study aimed at correlating the ileal microbiota composition of adult CD patients with methylation level of gene promoters related to inflammation and autoimmunity.

应用场景：

创建时间：

2018-08-17

克罗恩病微生物组

炎症黏膜菌群比较分析

Crohn's Disease (CD) pathogenesis is still unclear. Disorders in the mucosal immunoregulation and its crosstalk with the microbiota may represent an important component in tissue injury. We aimed to c

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Genome-wide analysis of DNA methylation profile provides clinical implication of Crohn’s Disease. Genome-wide analysis of DNA methylation profile provides clinical implication of Crohn’s Disease

DNA甲基化与疾病

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Inflammatory bowel disease (IBD) is known to be caused by a genetic predisposition involving multiple genes; however, there is growing evidence that abnormal interaction with environmental, particular

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Integrative Epigenome-Wide Analysis Shows That DNA Methylation May Mediate Genetic Risk In Inflammatory Bowel Disease [Whole blood, Methylation profiling]

炎症性肠病遗传学

DNA甲基化与疾病

Epigenetic alterations may provide important insights into gene-environment interaction in inflammatory bowel disease (IBD). Here we observe epigenome-wide DNA methylation differences in 240 newly-di

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Runde et al MAGs from Pediatric Crohn's Patients

克罗恩病微生物组

EEN治疗微生物响应

A collection of metagenome-assembled genomes reconstructed by Joseph Runde et al. from gut metagenomes of pediatric Crohn's disease patients who went through EEN therapy. Original metagenomes were

Figshare2021-08-04 更新80

Diversity of adhered microbial communities in colon mucosal biopsies of Crohn patients by 16S rRNA gene pyrosequencing, evidences for two main distinct groups.

克罗恩病微生物组

生物膜与黏膜微生物组

The mucosal adhered microbiota of 13 patients suffering from Crohn disease (CD) and 7 control cases (HC) had been studied by means of a high quality deep-sequencing of 16S rRNA gene amplicons, followe

NIAID Data Ecosystem70

Inactive Crohn’s disease ileal microbiota is linked to promoter methylation of genes involved in inflammation and autoimmunity

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