Macrophage depletion in diabetic CD11b-DTR mice restores PEDF protein expression to normal levels.
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https://figshare.com/articles/dataset/_Delayed_Treatment_with_a_Small_Pigment_Epithelium_Derived_Factor_PEDF_Peptide_Prevents_the_Progression_of_Diabetic_Renal_Injury_/1494242
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Male 6-wk-old B6.FVB-Tg(ITGAM-DTR/EGFP)34Lan/J (CD11b-DTR) mice (stock no. 006000, Jackson Laboratory, Bar Harbor, MN) were given multiple intraperitoneal injections of vehicle or STZ. A diphtheria toxin (DT) (List Biological Laboratories) was injected intraperitoneally at the dose of 25 ng/g body wt weekly for 6 wk after STZ injection [25]. Kidney tissues were homogenized in lysis solution as indicated in the Method section for western blot analysis of PEDF expression as we described previously [18]. Quantification was performed by densitometry followed by normalization to GAPDH. Results are means ± SEM for n = 4–5 mice in each group. *p<0.05 compared to diabetic CD11b-DTR mice treated with diphtheria toxins.
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创建时间：
2015-07-24
