Methods and compositions for targeted cleavage and recombination
收藏国家林业和草原科学数据中心2023-02-12 更新2024-03-07 收录
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资源简介：
Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence， targeted alteration of a genomic sequence， and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain and polynucleotides encoding same. Methods for targeted cleavage include introduction of such fusion proteins， or polynucleotides encoding same， into a cell. Methods for targeted recombination additionally include introduction of an exogenous polynucleotide homologous to a genomic region into cells comprising the disclosed fusion proteins.
提供机构：
国家林业和草原科学数据中心
创建时间：
2023-02-12
