Metagenomic profiling of the mouse microbiome

The mammalian gut microbiota consists of hundreds of anaerobic bacterial species that shape intestinal homeostasis and influence host immune responses. Although the causal roles of specific human gut bacterial species in health and disease are emerging, the role of indigenous gut bacteria in driving immunophenotypic variability in mouse models of human disease remains poorly understood. This study undertook metagenomic sequencing of mouse faecal samples pre- and post- DSS challenge to understand the role of pathobionts on disease phenotype.