Blood coagulation and complement activation interact to increase disease activity in systemic lupus erythematosus and coagulation D-Dimer combined with complement C4 is a biomarker of lupus activity

This study was conducted to (1) find deregulation of certain pathways in SLE at multi-omics levels; (2) evaluate the associations among blood coagulation, complement activation, inflammatory responses and SLE disease severity; (3) develop biomarkers to facilitate better the assessment of the likelihood of lupus activity.