Additional file 1 of Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

Table S1. Cohort-specific results from epigenome-wide association analyses of gestational age. Table S2. Normalization technique and phenotype definitions used by each cohort. Table S3. Bonferroni-significant CpGs from the meta-analysis on the association between continuous gestational age (no complications model) and offspring DNA methylation at birth adjusted for estimated cell counts. Table S4. Bonferroni-significant CpGs from the meta-analysis on the association between continuous gestational age (all births model) and offspring DNA methylation at birth adjusted for estimated cell counts. Table S5. Gene regions that had at least three consecutive Bonferroni significant CpG sites from the continuous gestational age analyses (no complications model). Table S6. DMRs (n = 2375) for gestational age in relation to newborn methylation (no complication model) identified by using both comb-p (P < 0.01) and DMRcate (FDR < 0.01) methods. Table S7. DNA methylation analyses in fetal lung tissue using the no complication gestational age three or more consecutive CpG list. Table S8. DNA methylation analyses in fetal brain tissue using the no complication gestational age three or more consecutive CpG list. Table S9. Methylation look-up analyses in older children using the no complication gestational age three or more consecutive CpG list. Table S10. Longitudinal analysis of methylation levels in the INMA and ALSPAC studies using the no complication gestational age three or more consecutive CpG list. Table S11. Gene Ontology (GO) term enrichment analyses for bonferroni-significant CpGs from the meta-analysis (no complications model). Table S12. KEGG pathway analyses for bonferroni-significant CpGs from the meta-analysis (no complications model). Table S13. Gene Ontology (GO) term enrichment analyses for three or more CpGs being localized to the same gene. Table S14. KEGG pathway analyses for stable and dynamic CpGs. Table S15. Correlation between methylation and gene expression levels in cord blood (cis-effects). Table S16. The replication of bonferroni-significant CpGs from the meta-analysis (no complications model) in previous publication.