The effects of TBBPA/TBBPS/TCBPA on human hepatic development

We evaluated the hepatic developmental toxicity of TBBPA/TBBPS/TCBPA with a human embryonic stem cells (hESC) system. We found that TBBPA/TBBPS/TCBPA might adversely affect human hepatocyte-like cells specification from hESCs via mainly impairing definitive endoderm specifications, suggesting the early stages of embryonic development are susceptible to the three compounds. We studied the toxicity behaviors of TBBPA, TBBPS and TCBPA in definitive endoderm and hepatoblast specification from hESCs by analyzing mRNA profiles with RNA-seq, in duplicate, respectively.