Joint Analysis of Genetic Correlation, Mendelian Randomization and Colocalization Highlights the Bi-directional Causal Association Between Hypothyroidism and Primary Biliary Cirrhosis

<b>Context:</b> Hypothyroidism and Primary biliary cirrhosis (PBC) are often co-existed in observational epidemiological studies. However, the causal relationship between them remains unclear. <b>Methods:</b> Genetic correlation, Mendelian randomization (MR) and colocalization analysis were combined to assess the potential causal association between hypothyroidism and PBC by using summary statistics from large-scale genome-wide association studies. Various sensitivity analyses had been conducted to assess the robustness and the consistency of the findings.