Gene expression profile at single cell level of mouse liver in whole and fibrotic niche of the liver [FiNi-seq]

Age-dependent fibrosis accumulated in the liver includes driver cell types of aging. We used single cell RNA sequencing (scRNA-seq) from specially digested liver to analyze the age-related fibrosis. Overall design: The liver was digested to enriched the fibrotic niche and was sequenced in parallel with control data. Experiment was done in CCl4-treated mouse to see early fibrosis niche