The lead associations in the three significantly associated loci in the chromosome X-wide association analysis.

EA: effect allele; OA: other allele; Data set: the data sets included in the meta-analysis: discovery cohorts (discovery), the replication cohort (replication), both discovery and replication cohorts (joint); Sex: the sex in which the analysis was conducted; EAF: effect allele frequency; Beta: effect size for the effect allele; SE: standard error for Beta; P-value: P-value for the association from fixed-effects meta-analysis; N: sample size in the analysis; P-value (sex): P-value for the association from sex-differentiated meta-analysis; P-value (het): P-value from the sex heterogeneity test; Variance explained: the proportion of phenotype variance the lead SNP explains in per cent, calculated from meta-analysis summary statistics (Materials and Methods).