Identification of differentially expressed genes in benign and malignant mammary gland tumors of dog and their role in cancers of mammary gland

Using microarray technology, we aim to identify genes affecting the biology of mammary tumor cancers in dogs. Canine mammary gland tumors (CMGTs) are the most common neoplasms in sexually intact female dogs. CMGTs have been suggested as a model for studying human breast cancer because of several similarities, including the relative age of onset, risk factors, incidence, histological and molecular features, biological behavior, metastatic pattern, and responses to therapy. Nine surgically resected tumors were collected and used in experimental analysis with respect to two healthy mammary glands. All samples were used in duplicates.