MSH2:MSH3 exchanges ADP for ATP

After binding a mismatch, the MSH2:MSH3 (MutSbeta) heterodimer exchanges ADP for ATP, which changes the conformation of MSH2:MSH3 to a sliding clamp or molecular switch able to diffuse in one direction along duplex DNA (Gu et al. 1998, Zhang et al. 2005, and inferred from MSH2:MSH6).

在MSH2:MSH3（MutSbeta）异源二聚体发生结合不匹配后，其将ADP与ATP进行交换，从而改变MSH2:MSH3的结构构象，转变为一种滑动夹或分子开关，能够沿双链DNA单向扩散（Gu等，1998年；张等，2005年，以及根据MSH2:MSH6推断）。