Zebrafish - modelling familialAlzheimer's disease using heterozygous K97fs mutation in locus psen1

RNA-seq analysis of whole brains from zebrafish possessing a heterozygous K97fs mutation in psen1 to model familial Alzheimer's disease Total RNA was extracted from the whole brains of mutant and wild type zebrafish when they were either 6-months-old (young adult) or 24-months-old (infertile adult). Mutant zebrafish possess a heterozygous K97fs mutation at the endogenous zebrafish psen1 locus while wild type zebrafish do not.