CT26-derived MSS-CRC mice

NIAID Data Ecosystem2026-05-01 收录

MSS结直肠癌免疫治疗

Wnt信号通路抑制

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1086657 数据链接链接失效反馈

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This distinctive design presents a strategic approach with promising clinical translational prospects for suppressing Wnt signaling in MSS-CRC but also supports the feasibility of reactivating anti-tumor immunity following blockade of the Wnt pathway.

创建时间：

2024-03-11

Blockade of Wnt secretion by LGK974 after ischemia reperfusion injury. Blockade of Wnt secretion by LGK974 after ischemia reperfusion injury

心肌缺血再灌注损伤

Wnt信号通路抑制

The LAD of C57BL6 mice were temporally occluded to induce ischemia-reperfusion injury of the heart. Mice received a daily dose of the porcupine inhibitor LGK974 starting directly after the surgery to

NIAID Data Ecosystem50

The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin

癌症干细胞治疗

Wnt信号通路抑制

Tumors are phenotypically heterogeneous and include subpopulations of cancer cells with stemlike properties. The natural product salinomycin, a K+-selective ionophore, was recently found to exert sele

NIAID Data Ecosystem40

Target – ligand interaction energies of secondary metabolites from C. pulcherrima and the positive control and their previously reported Wnt/β-catenin pathway inhibitory and anti-proliferative activities.

Wnt信号通路抑制

抗癌药物筛选

NIAID Data Ecosystem20

Effect of inhibition of CBP-coactivated β-catenin-mediated Wnt signalling in uremic rats with vascular calcifications

糖尿病血管钙化

Wnt信号通路抑制

Uremic vascular calcification is a regulated cell-mediated process wherein cells in the arterial wall transdifferentiate to actively calcifying cells resulting in a process resembling bone formation.

NIAID Data Ecosystem50

Gene expression in dorsal halves of Apcdd1-depleted Xenopus laevis embryos. Gene expression in dorsal halves of Apcdd1-depleted Xenopus laevis embryos

发育基因调控

Wnt信号通路抑制

apcdd1, a gene mutated in hereditary hypotrychosis simplex, is a maternally expressed gene in Xenopus embryos, required for correct formation of anterior and dorsal structures. Initial data suggested

NIAID Data Ecosystem40

CT26-derived MSS-CRC mice

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