Transcatheter Aortic Valve Replacement and the Role of Multidetector Computed Tomography in Anatomical Assessment and Enhancing Clinical Outcomes

The thesis evaluates the application of computed tomography (CT) imaging in both pre-procedural and post-procedural transcatheter aortic valve replacement that may influence clinical and procedural outcomes. CT-defined leaflet thrombosis following valve implantation was the focus of this thesis. Innovative findings from this body of work include a novel quantification method for thrombus burden, demonstrating the influence of prosthesis geometry and design on clot formation, the adverse haemodynamic impact of thrombus on valve durability and the association of leaflet thrombosis with cerebrovascular events.