Transcriptional profiling of YF-naïve participants after vaccination against yellow fever.

Mechanisms of poor responses to vaccines remain unknown. Yellow fever-naïve adults were vaccinated with a yellow fever vaccine (YF-17D, Stamaril). Transcriptomic profilling of blood collected pre-vaccination and post-vaccination (day 3, 7, 14 and 84) was performed in order to identify candidate biomarkers of antibody response to the vaccine. Post-vaccination transcriptomic profiling at days 3, 7, 14 and 84 and other immune parameters have been investigated in association with the immune response, at day 80 post-vaccination, to Yellow Fever vaccine (YF-17D) in a cohort of 36 participants recruited in Entebee (Uganda).