Rapid Construction of Vinyl Indomorphans by Rhenium Catalysis
收藏NIAID Data Ecosystem2026-05-01 收录
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Here, an efficient route for accessing the vinylindomorphan skeleton is achieved by rhenium(I) catalysis. This transformation involves the condensation of indoles and alkyne-linked cyclohexanones, followed by intramolecular annulation to build the [3.3.1] bicyclic structure. This protocol complements the synthesis of the structurally complex heterocycles bearing a vinyl indole moiety. In addition, the selected products exhibited moderate cytotoxicity toward human A549 cells.
创建时间：
2023-11-17
