Crystal structure of the human METTL3-METTL14 complex bound to Compound 7 (ADO_AC_074)

Crystal structure of the human METTL3-METTL14 complex bound to Compound 7 (ADO_AC_074) Descriptor: 6-[4-[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]-N-(phenylmethyl)pyrimidin-4-amine, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... Authors: Bedi, R.K, Dolbois, A, Caflisch, A. Deposit date: 2021-03-25 Release date: 2021-09-01 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: 1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors. J.Med.Chem., 64, 2021