Data_Sheet_1_Emergence of Progressive Mutations in SARS-CoV-2 From a Hematologic Patient With Prolonged Viral Replication.pdf

We documented a hematologic patient with prolonged SARS-CoV-2 viral replication in whom emergence of viral mutations was documented after the consecutive use of antivirals and convalescent plasma. The virus detected in the last of 12 clinical samples (day 237) had accumulated 22 changes in amino acids and 29 in nucleotides. Some of these changes, such as the E484Q, were mutations of concern as defined by WHO. This finding represents an enormous epidemiological threat and poses a major clinical challenge. Combined antiviral strategies, as well as specific strategies related to the diagnostic approach of prolonged infections for this specific population, may be needed.

我们对一位患有长期SARS-CoV-2病毒复制的血液病患者进行了记录，该患者在连续使用抗病毒药物和康复期血浆治疗后，病毒发生了突变。在12个临床样本中的最后一个样本（第237天）中检测到的病毒，其氨基酸发生了22次变化，核苷酸发生了29次变化。其中一些变化，如E484Q突变，根据世界卫生组织（WHO）的定义，属于值得关注的变化。这一发现代表了一种巨大的流行病学威胁，并构成了重大的临床挑战。对于这一特定人群的长期感染，可能需要结合抗病毒策略以及与其诊断方法相关的特定策略。