Proteomic analysis of bone marrow-derived macrophages after Nano-IFNγ/Zole and GGPP incubation
收藏国家人口健康科学数据中心2026-06-01 收录
下载链接：
https://www.ncmi.cn/phda/dataDetails.do?id=CSTR:17970.11.A001G.202407.83.V1.0
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资源简介：
We designed and prepared a bisphosphonate-mineralized Nano-IFNγ (Nano-IFNγ/Zole) to promote trans-differentiation of macrophages from the M2 to M1 type. Bisphosphonate in the Nano-IFNγ/Zole reduced lysosomal acidification by inhibiting isoprene modification of Rab family proteins, enhanced tumor antigen cross-presentation and activated the TFEB pathway. These mechanisms, in conjunction with IFNγ-activated JAK/STAT1 signaling, facilitated the trans-differentiation of macrophages.
提供机构：
北京蛋白质组研究中心
创建时间：
2024-07-05
