DNA methylation sites significantly associated with anti-dsDNA autoantibody production using the discovery/replication study design.

a Unadjusted difference in DNA methylation between anti-dsDNA positive and anti-dsDNA negative SLE cases [methylation(anti-dsDNA positive)-methylation(anti-dsDNA negative)] b Mean difference represents the coefficient from the linear regression model which indicates the difference in DNA methylation between anti-dsDNA positive and negative SLE cases adjusted for age, disease duration, sample plate, population substructure, and estimated leukocyte proportions c OR represents the odds of being anti-dsDNA autoantibody positive if an individual’s DNA methylation level is in the lowest tertile compared to the highest tertile, adjusted for age, disease duration, sample plate, population substructure, and estimated leukocyte proportions DNA methylation sites significantly associated with anti-dsDNA autoantibody production using the discovery/replication study design.