Microglia-like cells derived from patients with panic disorder

We used a model to induce patient-derived microglia-like cells (iMGs) to clarify the molecular characteristics and function of Panic disorder patient-iMGs (PD-iMGs). We established iMGs from 14 PD patients and 10 healthy controls (non-psychiatric controls, HC). We analyzed the phenotype of the PD-iMGs by RNA sequencing. The PD-iMGs clustered together distinct from HC-iMGs. Gene set enrichment analysis revealed the involvement of cholesterol biosynthesis and steroid metabolism in PD-iMGs. The human RNA sample which was collected from peripheral blood monocytes derived microglia-like cells of 10 Healthy control individuals and 14 Panic disorder patients were sequenced. Please note that the previous processed data files (with incorrect gene symbols) have been replaced on Nov 15, 2022.