miRNA expression signatures of acne inversa (AI) patients with NCSTN mutations and healthy individuals

To elucidate the relationship between NCSTN mutations and familial AI pathogenesis by investigating differential miRNA expression, we have employed miRNA microarray profiling as a discovery platform to identify miRNA with the potential to be involved in familial AI pathogenesis. Skin biopsies were obtained from the lesions of AI patients with NCSTN mutations . Control skin tissues were obtained from healthy individuals undergoing cosmetic surgery procedures Two groups, AI patients with NCSTN mutations vs. healthy individuals. Each group contains 5 samples.