ABSTRACT Aromatase is a cytochrome P450 enzyme (CYP19A1 isoform) able to catalyze the conversion of androgens to estrogens. The aromatase gene mutations highlighted the action of estrogen as one of th
Average endogenous level of unlabelled free CoA (CoASH), acetylCoA and total CoA in male C57/Bl6 mouse brain (n = 27) during the intrastriatal infusion study over a period of 336 h after dosing.
As the desire for a shortened design/make/test/learn cycle increases in early drug discovery, the pressure to rapidly deliver drug metabolism pharmacokinetic data continues to rise. From a bioanalytic