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Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells

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Figshare2016-01-15 更新2026-04-29 收录
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Statins are widely used in the treatment of hypercholesterolemia and are efficient in the prevention of cardiovascular disease. Molecular mechanisms explaining statin-induced impairment in insulin secretion remain largely unknown. In the current study, we show that simvastatin decreased glucose-stimulated insulin secretion in mouse pancreatic MIN6 β-cells by 59% and 79% (p

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2016-01-15
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