Main pharmacokinetic parameters for coumarin (COU), 7-hydroxycoumarin (7-HCOU) and o-coumaric acid (OCA) in human plasma after oral administration of 60 mL of guaco syrup spiked with 1500 mg of coumarin (n = 5).

Data: Cmax: maximum concentration of drug in human plasma observed at a particular time point; Tmax: time at which maximum concentration of drug in plasma was observed; AUC0–t: area under plasma concentration—time curve; AUC0–∞: area under plasma concentration curve extrapolated to infinity; T1/2: time required for decomposition of the drug to half of the concentration; Kel: elimination rate constant; Vd/f: apparent volume of distribution; Cl/f: apparent rate at which a substance is removed or cleared from the body;asignificantly different from coumarin;bsignificantly different from 7-HCOU (Student t test, 95% confidence).Main pharmacokinetic parameters for coumarin (COU), 7-hydroxycoumarin (7-HCOU) and o-coumaric acid (OCA) in human plasma after oral administration of 60 mL of guaco syrup spiked with 1500 mg of coumarin (n = 5).