Novel genetically engineered mouse models for clear cell renal cell carcinoma with somatic mutations in Bap1, Pbrm1 and Setd2
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE199795
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Kidneys from our advanced GEMMs of early stage cancer renal cancers contain low frequent somatic mutations in Bap1, Pbrm1 and Setd2, enhanced immune clearance and activation of the DNA damage response We performed RNAseq on kidney cortex samples from transgenic mice with constitutive activation of HIF1A and gene edits in Bap1,Pbrm1 and compared gene expression to kidneys from wild type mice
创建时间：
2023-08-11
