Synthesis of Multisubstituted 1‑Naphthoic Acids via Ru-Catalyzed C–H Activation and Double-Alkyne Annulation under Air
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An efficient [2 + 2 + 2] benzannulation of phthalic acids/anhydrides with two alkynes was developed for synthesis of multisubstituted 1-naphthoic acids via Ru-catalyzed C–H activation. The reaction preceded well using atmospheric oxygen as the sole oxidant with high atom/step economies. Facilitated by the free carboxyl group, the products can be easily converted to diverse polycyclic molecules.
创建时间：
2019-06-13
