Stereospecific Transformation of Protected P–H Group into P–O or P–N Group in One-Pot Reaction
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https://figshare.com/articles/dataset/Stereospecific_Transformation_of_Protected_P_H_Group_into_P_O_or_P_N_Group_in_One_Pot_Reaction/2462317
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资源简介：
A general and efficient procedure for converting 1,1-diethoxyalkylphosphinates
into phosphonates or phosphonamides is described by the application
of bromine with moderate to high yields and good purity in a one-pot
reaction. H-Phosphinate reacts stereospecifically
with bromine and subsequently couples with nucleophile to form the
corresponding optically active R1P(O)(OEt)X with retention
of configuration at the phosphorus center. For α-amino-H-phosphinates, the transformation could be realized without
the protection of the amino group.
创建时间：
2012-12-07
