Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions (3)

Here we report transcriptional and TCR specificities associated with murine open repertoire CD45.1+ CD4+ and CD4+CD8+, and CD45.2+ CD8+ and CD8+CD4+ T cells isolated from murine B16 tumors Overall design: Single cell TCR/RNA sequencing was performed on sorted open repertoire CD45.1+ CD4+ and CD4+CD8+, and CD45.2+ CD8+ and CD8+CD4+ T cells isolated from murine B16 tumors.