raw data for metabolomics and transcriptomics
收藏科学数据银行2024-02-07 更新2026-04-23 收录
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https://www.scidb.cn/detail?dataSetId=647ca2bbfa39443c9d6829cc77f89379
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资源简介：
This dataset is the raw data for metabolomics and transcriptomics. After administering quinic acid orally to high-fat mice, changes in brain neuroinflammation were observed. Metabolomics revealed a significant increase in tryptophan metabolites indole-3-acetic acid and kynurenic acid, suggesting that quinic acid may be metabolized into tryptophan by gut microbiota. Then, these two substances were further administered orally to high-fat mice, and the same trend as quinic acid was observed. Transcriptomic analysis revealed that indole-3-acetic acid was expressed through DR3/IKK/NF- κB signaling pathway inhibits neuroinflammation in the brain.
提供机构：
University of Shanghai for Science and Technology; Wanqing Cao; Yuwei Cai
创建时间：
2024-02-04
