Base model PK parameter estimates.

The full (56 subjects, 577 plasma concentrations) and reduced (35 subjects, 388 plasma concentrations) datasets were used. Parameters: CL, clearance; V1, volume of central compartment; Q, inter-compartmental clearance; V2, volume of peripheral compartment (units are noted in parenthesis). BSV and BOV are listed as %CV. Θ, typical value of the PK parameters; BSV, between-subject variability; BOV, between-occasion variability.