Lewis Acid Promoted Diastereoselective Addition of TMSCN and TMSCF3 to Isatin-Derived N‑Sulfinyl Ketimines: Synthesis of Optically Active Tetrasubstituted 3‑Aminooxindoles
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A practical and efficient method for preparation of highly enantiomerically enriched 3-cyano-3-aminooxindoles and 3-trifluoromethyl-3-aminooxindoles with up to 99% optical purity by a Lewis acid promoted diastereoselective Strecker reaction and trifluoromethylation of isatin-derived N-tert-butanesulfinyl ketimines has been developed. This protocol allows direct use of N-free isatin substrates under mild conditions.
创建时间：
2016-02-17
