Epigenetic landscape of Human Brain by Single Nucleus Methylation Sequencing

Illustrating the cellular architecture of the human brain is critical to understanding its diverse functions and complex animal behaviors. Single nucleus methylation sequencing was applied to regions of human brains. we identified distinct cell clusters and formed them in a hierarchical taxonomy. These clusters include known primary brain cell types and possible sub-types. We use these data to identify the epigenomic characteristics and to define specific regulatory elements for each cell cluster. Apply snmC-seq3 to brain regions to identify epigenomic landcape of the adult human brains. 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