The methylomes of different hsdS variants of these pathogens. Treponema denticola; Bacteroides fragilis; Enterococcus faecalis; Streptococcus agalactiae; Streptococcus pneuomoniae

Site-specific recombinations in the DNA methyltransferase hsdS genes of the type-I R-M systems may serve an important function(s) in promoting epigenetic and phenotypic diversity among the prokaryotic organisms. However, it remains unclear if DNA inversions in the hsdS genes occur in the type-I RM loci of pathogenic bacteria beyond the well-characterized hsdS recombinations in M. pulmonis and S. pneumoniae