Expression of foetal gene Pontin is essential in protecting heart against pathological remodelling and cardiomyopathy

Cardiac remodelling is a key process in the development of heart failure. Reactivation of foetal cardiac genes is often associated with cardiac remodelling, which might be the result of the activation of signalling pathways involved in heart failure. Here we studied the role of Pontin (Ruvbl1), which is highly expressed in embryonic hearts, in mediating adverse remodelling in adult mouse hearts.