We present a CRISPR-Cas9 screen in human cancer cells to identify genes that confers tumors with the ability to evade the cytotoxic effects of the immune system. We discovered that the transcriptional
Annexin A1 (ANXA1) is a Ca2+-binding protein involved in pancreatic cancer (PC) progression. It is able to mediate cytoskeletal organization maintaining a malignant phenotype. ANXA1 Knock-Out (KO) MIA
Targeted gRNA screen against putative nucleic-acid binding proteins in a differentiation reporter strain context. By looking for gRNAs enriched in parasites no longer able to activate reporter express
Cell-permeable peptides (CPPs) allow intracellular delivery of cargo molecules that are hooked to them. CPPs provide an efficient methodology to transfer bioactive molecules in cells, in particular in
