Genomic variants associated with angina and health status outcome after MI. Genomic variants associated with angina and health status outcome after MI

Black patients with myocardial infarction (MI) have worse outcomes than white patients, including higher mortality, more angina, and worse quality of life. The TRIUMPH study was designed to examine whether racial differences in socioeconomic, clinical, genetic, metabolic, biomarker or treatment characteristics mediate observed disparities in outcomes. Between June 1, 2005 and December 31, 2008, 31567 patients with MI were prospectively screened, 6152 had an eligible MI, and 4340 (71%) were enrolled from 24 US centers. Consenting patients had detailed chart abstractions of their medical history and processes of inpatient care, supplemented with a detailed baseline interview. Detailed genetic and metabolic data were obtained at hospital discharge in 2979 (69%) and 3013 patients (69%), respectively. In a subset of patients, blood and urine samples were obtained at 1-month (obtained in 27% of survivors) and blood samples at 6-months (obtained in 19% of survivors... (for more see dbGaP study page.)