Effects of coexpression with the β1 subunit on the kinetics of sodium current activation and inactivation and amplitudes of persistent currents in HEK293 cells expressing Nav1.6 sodium channels.

a Time to peak current (ms) and first-order time constant (τinact, ms) of sodium current inactivation; values are means ± SE for the indicated number of replicate experiments with different cells.b Current measured at the end of a 40-ms depolarizing pulse expressed as a percentage of the peak current in the same depolarization; values are means ± SE for the indicated number of replicate experiments with different cells.c Significantly different from the value for Nav1.6 channels (P