Human CD29+/CD56+ myogenic progenitors display tenogenic differentiation potential and facilitate tendon regeneration

Tendon injury occurs at high frequency and is difficult to repair. Identification of human stem cells being able to regenerate tendon will greatly facilitate the development of regenerative medicine for tendon injury. Genetic and functional analyses identify human CD29⁺/CD56⁺ myogenic progenitors with tenogenic differentiation potential in vitro and in vivo. Transplantation of human CD29+/CD56+ myogenic progenitors contributes to injured tendon repair and thus improves locomotor function. Interestingly, the tendon differentiation potential in mouse muscle stem cells is minimal and the higher TGFβ signaling level may be the key for the distinct feature of human CD29+/CD56+ myogenic progenitors. The discovery of bi-potential CD29⁺/CD56⁺ myogenic progenitors highlight their potential as a novel adult stem cell source for tendon regeneration., , # Human CD29+/CD56+ myogenic progenitors display tenogenic differentiation potential and facilitate tendon regeneration

Dataset DOI: [10.5061/dryad.b2rbnzss8](10.5061/dryad.b2rbnzss8)

## Description of the data and file structure

Data of RT-qPCR results, immunofluorescence staining, bio-mechanical test, force test, and treadmill exercise test.

### Files and variables

#### File: fig1e.xlsx

**Description:** Proportion of CD29+/CD56+ myogenic progenitors in a specific cell population

##### Variables

* CD29+/CD56+ myogenic progenitors
* Total CD29+/CD56+ cells
* Total myogenic progenitors

#### File: fig1g.xlsx

**Description:** Statistical analysis of the percentage of PAX7+, MYOD1+, and MYF5+ cells in the isolated CD29+/CD56+ myogenic progenitors.

##### Variables

* PAX7+, MYOD1+ and MYF5+ cells
* DAPI+ cells

#### File: fig1h.xlsx

**Description:** Analysis of cell proliferation for human CD29+/CD56+ myogenic progenitors in vitro. 10,000 isolated human CD29+/CD56+ myogenic pro...,