Summary of statistics of signature sites of associated with serum neutralizing breadth and potency.

This table is organized similarly to Table 2.
1Variable loop lengths and the number of glycosylations sites in each variable loop were compared as in Table 1B, using a simple Spearman's rho test. We validated these results using a phylogenetically corrected method, phylogenetic contrasts [120], [121].
2In this column the number of “sites” refers to the number of sites considered in combination in each test, the number “deep” refers to how amino acids at a single site were combined in each test. k = 2 or 3 refers to the k-means clusters as illustrated in Fig. 5. When k = 3, the test could either be the lowest or the highest neutralization potency cluster versus all others. When k = 2, only the high and the low clusters were compared, excluding indeterminate values. Full Env means the complete Env was scanned in the test. CoRbs means the signature was defined in the in-depth scan of the CoRbs. No significant signatures were found in comparable in-depth scans of the CD4bs and the MPER regions.