SARS-CoV-2 infects human pluripotent stem cell-derived cardiomyocytes, impairing electrical and mechanical function

RNA-sequencing used to investigate the transcriptome response to Sars-cov-2 in ESC differentiated female cardiomyocytes and iPSC differentated male cardiomyctes Overall design: ESC differentiated female cardiomyocytes, subtype H7 infected with Sars-cov-2 at MOI of 0.1 (collected at 48hrs and 72hrs) and 5 (collected at 24hrs and 48 hrs) compared to mock (each done in triplicate) and iPSC differentiated male cardiomyocytes, subtype WTC infected with Sars-cov-2 at MOI of 0.1 (collected at 48hrs and 72hrs) and 5 (collected at 24hrs and 48 hrs) compared to mock (each done in triplicate)