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A fully validated blood stem/progenitor cell regulatory network reveals mechanisms of cell state stabilisation

ChEBI2016-03-17 更新2026-07-12 收录

造血干细胞调控

细胞状态稳定机制

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-69776 数据链接链接失效反馈

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资源简介：

A fully validated blood stem/progenitor cell regulatory network reveals mechanisms of cell state stabilisation

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创建时间：

2016-03-17

造血干细胞调控

细胞命运决定

The mammalian blood system is a hierarchically structured tissue. Hematopoietic stem cells (HSC) reside at the top of this hierarchy and the HSC-derived progenitor cells (HPC) have capacities for both

NIAID Data Ecosystem60

Convergence of Hypoxia and TGFβ Pathways on Cell Cycle Regulation in Human Hematopoietic Stem/Progenitor Cells

造血干细胞调控

缺氧响应机制

Although it has been shown that HIF1 and 2 fulfill essential roles within the hematopoietic system and in the regulation of HSC fate, little is currently known about the specific mechanisms that are i

NIAID Data Ecosystem50

Gene expression profile of HSCs from Angptl2fl/fl or Cdh5-Cre;Angptl2fl/fl mice

造血干细胞调控

内皮细胞-干细胞信号转导

To identify the intracellular targets of endothelial cell-specific ANGPTL2 that control HSC stemness, HSCs from Angptl2fl/fl or Cdh5-Cre;Angptl2fl/fl were sorted, followed by the extraction of total

NIAID Data Ecosystem40

ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation

造血干细胞调控

转录因子功能分析

To investigate the role of the transcription factor ERG in hematopoiesis we generated Erg heterozygous knockout and conditional Erg knockout mice. We found that several hematopoietic cell types were d

NIAID Data Ecosystem60

In Vivo Analysis of Retroviral Enhancer Mutations in Hematopoietic Cells: SP1/EGR1 and ETS/GATA Motifs Contribute to Long Terminal Repeat Specificity

造血干细胞调控

逆转录病毒增强子功能

The objective of this work was to identify, in the context of chromosomally integrated DNA, the contribution of defined transcription factor binding motifs to the function of a complex retrovirus enha

PubMed Central40

A fully validated blood stem/progenitor cell regulatory network reveals mechanisms of cell state stabilisation

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