RNA-Seq analysis of Sleep deprivation in wildtype and Shank3 mutant mice

This dataset constitutes the first RNA-Seq study of gene expression following sleep deprivation in wildtype and Shank3 exon 21 mutant mice Overall design: 20 total samples were analyzed, including wildtype and mutant (Shank3e21-/-) mice. Pre-frontal cortex tissue was collected at 5 hours of sleep deprivation (SD5). Animals that were left to sleep in their homecage were dissected at the same time of day to control for variations due to circadian rhythms (HC5). The protocol was repeated over the course of 5 days to obtain 5 animals per group, so that 5 independent SD experiments were represented in each time point and all animals for each group were dissected at exactly the same time of day.