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The Evolutionarily Conserved piRNA Producing Locus pi6 Is Required for Male Mouse Fertility

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NIAID Data Ecosystem2026-03-11 收录
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We report the generation and characterization of mouse mutants that do not produce piRNAs from a pachytene piRNA-producing locus on chromosome 6 (pi6). For molecular characterization, we generated RNA-seq, small RNA-seq, and degradome libraries from the sorted testicular germ cells from wild-type (C57BL/6), two independent alleles of pi6 mutant (pi6em1/em1 and pi6em2/em2), and pi17-/- mice.

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2020-05-31
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