Relative risk (95% CI) of primary gallbladder cancer, by z-scores of metabolic factors, and of the MetS score (n = 575,390).

1Relative risks were estimated from Cox regression models after excluding the first year of follow-up after baseline measurement, with attained age as time scale, stratified by cohort, sex and categories of birth year, adjusted for baseline age and smoking status, and corrected for regression dilution bias by use of regression dilution ratio (RDR); conversion into uncorrected RR = exp (log (RR)*RDR). RDR: BMI, 0.90; mean blood pressure, 0.54; log(glucose), 0.28; cholesterol, 0.66; log(triglycerides), 0.51.2Additionally adjusted for BMI.3Further adjusted for all the individual z-scores (except in MetS score analysis). In addition, z-scores, derived from original values, were calibrated.4Glucose and triglycerides were logarithmically transformed.Abbreviations: CI, confidence interval; MetS, metabolic syndrome; BMI, body mass index; RR, relative risk.