Mechanism exploration and clinical verification of new integrated markers of capecitabine clinical effect

Interventions: Capecitabine:Nil;Capecitabine + Bevacizumab/ Cetuximab:Nil;Capecitabine + Oxaliplatin:Nil;Capecitabine + Oxaliplatin + Bevacizumab/Cetuximab:Nil;Capecitabine + radiotherapy:Nil;Irinotecan + capecitabine:Nil Primary outcome(s): Three-year disease-free survival Study Design: Non randomized control